The Expression of S100A4 Protein in Different Thyroid Tissue and Associated with Metastasis of Thyroid Cancer

Objective: To investigate the expression of S100A4 protein in different thyroid tumor and related with metastasis.Methods: The expression of S100A4 protein was detected in 130 cases of thyroid tissue by immunohistochemistry.There were 55 cases of papillary thyroid carcinoma and 30 cases of matched samples of adjacent normal thyroid tissue,15 cases of follicular thyroid carcinoma,10 case of medullar thyroid carcinoma,50 cases of benign thyroid neoplasm(25 cases of simple benign multimodal goiters and 25 cases of follicular adenoma),5 cases of normal thyroid tissue.Results:The positive expression rate of S100A4 protein in thyroid carcinoma was 77.5%(62/80)and 16.0%(8/50)in benign thyroid neoplasm.The expression rate of S100A4 protein was negative in normal thyroid tissues and samples of adjacent normal thyroid tissue.The positive expression rate in thyroid carcinoma was much higher than that in benign thyroid neoplasm and in normal thyroid tissue(P0.01).The positive rate of S100A4 was 83.3%(25/30)in the group with lymph node metastasis and 74.0%(37/50)in the group without lymph node metastasis thyroid carcinoma.There was significant difference between two groups(P0.05).In 30 cases of primary tumors and their matched lymph node metastasis,the expression of S100A4 in matched lymph node metastasis tissues was higher than its primary thyroid carcinoma(P0.01).Conclusion: Over expression of S100A4 may be closely related with the metastases in thyroid carcinoma.S100A4 might be useful as one of the valuable markers for patients with thyroid carcinoma in progression.