Detection of estrogen receptor in papillary thyroid carcinoma

Objetive:To study the clinical and pathological significance of estrogen receptor expression in papillary thyroid carcinoma.Methods:Expression of estrogen receptor (ER) were detected by immunohistochemistry SP method in 80 cases of thyroid papillary carcinoma and 30 cases of follicular carcinoma and 50 cases of pericancerous normal thyroid tissue. Results:The positive rate of ER was 67.5%(54/80) in papillary carcinoma, 23.33%(7/30) in follicular carcinoma,and 6%(3/50) in normal thyroid tissue.The results showed that the positive rate in papillary carcinoma was significantly higher than that in follicular carcinoma and normal thyroid tissue.The positive rate in primary papillary carcinoma was significantly higher than that in cases of recurrence,the positive rate in cases without neck lymph node metastasis was significantly higher than that in cases with neck lymph node metastasis,the positive rate in female was significantly higher than that in male.Conclusion:Thyroid papillary carcinoma was associated with estrogen,and detection of ER in thyroid papillary carcinoma was helpful for the treatment.