Effects of tangzhixiao on insulin sensitivity in insulin-resistant hypertensive rats

AIM:To observe the effects of different doses of tangzhixiao on insulin sensitivity in high fructose-fed rats and to explore its mechanism.METHODS:Insulin-resistant(IR) models established in male Sprague Dawley rats were randomly divided into three groups.Rats were given a high-fructose diet or high-fructose diet containing two doses of tangzhixiao.Fasting blood glucose(FBG),fasting insulin(FINS) and LP were measured after 4 weeks.The HOMA model was used to evaluate IR.RESULTS:In rats fed with high fructose,LP was positively related to FINS and HOMA-IR.FINS,LP and HOMA-IR of different doses of the tangzhixiao group decreased compared with those in the control group,but significant changes were found only in high-dose tangzhixiao group(all P0.05).CONCLUSION:Tangzhixiao greatly prevents IR,possibly by decreasing leptin levels.