Effect of high-fructose diet on insulin sensitivity and blood pressure in rats

Objective To evaluate the effects of high-fructose diet on serum insulin sensitivity and blood pressure. Methods Twenty-four male Sprague-Dawley rats were divided into two groups: control group fed with normal rat chow, and high-fructose(HF) group fed with HF diet (60% fructose) for four weeks. The body weight, systolic blood pressure (SBP), fast blood glucose (FBG), serum insulin (FSI), triglyceride (TG), and insulin sensitivity index (ISI) were measured in two groups. Results Compared with control group, blood pressure significantly increased after fed with high-fructose diet for 2 weeks in HF group. After 4 weeks, hyperinsulinemia, insulin resistance, and hypertriglyceridemia occurred in HF group. But there was no significant difference in body weight and mean feeding stuffs per day between two groups. Conclusion The high-fructose induced SD rat model is characterized by typical insulin resistance and hypertension, which may be an ideal animal model for investigating insulin resistance and hypertension.