Effects of Tangzhixiao on Insulin Resistance and Leptin Level in Insulin Resistant Hypertensive Rats

Objective To observe the effects of Tangzhixiao on insulin resistance and leptin level in high fructose-fed rats.Methods Male Spraque-Darley rats were fed on high fructose diet to establish insulin resistant hypertensive rat model and then randomly divided into three groups.The rats were given high fructose diet or high fructose diet containing two doses of TangZhixiao for 4 weeks. The concentrations of serum glucose,insulin and leptin were determined. The HOMA model was used to evaluate insulin resistance(IR).The relationships between each parameter were analyzed.Results (1)SBP,insulin level and HOMA-IR in rats fed on high fructose were significant higher than those in normal control group,following hyperleptinemia(P0.05 or P0.01).(2)In rats fed on high fructose,leptin was positively related to SBP and insulin ,while negatively to HOMA-IR (all P0.05).(3)The insulin,leptin and HOMA-IR of high dose of Tangzhixiao group were decreased than those in model control group(all P0.05).Conclusion High fructose diet can induce insulin resistance,hypertension and hyperleptinemia in the SD rats.Tangzhixiao can effectively prevent insulin resistance.The mechanism of Tangzhixiao preventing insulin resistance may be obtained by decreasing leptin level.