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Study of Protective Effect of Jindangantai in Active Liver Injury Model of Rats

Xi Yang

Abstract

Objective:To testify the protective effect of jindangantai on liver injury. Methods:40 rats were randomly divided into a normal group(10 rats) and acute liver injury models(30 rats) indued by G galactosamine(D GalN). The models were divided into liver injury group, yiganning group, and jingdangantai group(10 rats each). The normal group and liver injury group were given no treatment, while yiganning group were given yiganning pills 6.0 g·kg 1 ·d 1 and jingdangantai group were given jingdangantai 10.0 g·kg 1 ·d 1 , both by perfusation for 7 days. Serum alanine transaminase(ALT) and aspartic transaminase(AST) were detected. Changes of histopathology were observed by light microscopy. Results:The levels of ALT and AST were markedly decreased in Jingdangantai group compared with D GalN group ( P 0.05).The pathological injury was alleviated obviously. Conclusion: jingdangantai has a significant protective effect on liver cells.

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Key concepts: Liver injury, Histopathology, Alanine transaminase, Normal group, Internal medicine, Aspartate transaminase, Medicine, Galactosamine