Protection of Shenguiruangan Capsule on Acute Liver Injury

Objective To study the protective effect of Shenguiruangan capsule(SGRG) on acute liver injury induced by D-galactosamine in mice. Methods Seventy-two mice were randomly divided into six groups: normal control group,liver injury model group,positive control group,low(1.35 g/kg),middle(2.7g/kg),high(5.4 g/kg) doses of SGRG groups;the drug groups were administered ig for 7 days,twice a day,instead of that the normal control group and the model group were simultaneously administered with physiological salt solution;The acute liver injury model was induced by D-galactosamine(800 mg/kg) ip at the time of one hour after the last ig.24 hours later,the levels of ALT,AST in serum and MDA content in myocardial homogenate were measured,and liver injury was also observed by pathological examination. Results SGRG could reduce the level of ALT,AST and MDA;and pathologically,SGRG also showed its protective effect in lessening liver injury induced by D-galactosamine. Conclusion SGRG has a powerful protective effect on acute liver injury induced by D-galactosamine.