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18α glycyrrhizic acid in the treatment of acute liver injury induced by D-galactosamine in rats

Wang Pei

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Abstract

Objective To observe the treatment with 18-α glycyrrhizic acid(18-α-GA) for acute liver injury induced by D-galactosamine(GalN) in rats.Methods Sixty rats were randomly divided into six groups.Except the negative control group,the other groups were intraperitoneally injected with 10% GalN 500 mg/kg.Three days prior to the GaIN treatment 18α-GA was intraperitoneally injected with 15,30,and 60 mg/kg once per day After 30 h of GalN treatment,serum ALT and AST were detected and the left lobes of the liver were histologically examined.Results 18α-GA could significantly inhibit the level of serum ALT and AST,and reduce the pathological damage in acute liver injury of the rats.Conclusion 18α-GA has the potential to prevent and treat acute liver injury induced by GalN in the rats.

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What this paper is about

Objective To observe the treatment with 18-α glycyrrhizic acid(18-α-GA) for acute liver injury induced by D-galactosamine(GalN) in rats.Methods Sixty rats were randomly divided into six groups.Except the negative control group,the other groups were intraperitoneally injected with 10% GalN 500 mg/kg.Three days prior to the GaIN treatment 18α-GA was intraperitoneally injected with 15,30,and 60 mg/kg once per day After 30 h of GalN treatment,serum ALT and AST were detected and the left lobes of the liver were histologically examined.Results 18α-GA could significantly inhibit the level of serum ALT and AST,and reduce the pathological damage in acute liver injury of the rats.Conclusion 18α-GA has the potential to prevent and treat acute liver injury induced by GalN in the rats.

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Available abstract

Objective To observe the treatment with 18-α glycyrrhizic acid(18-α-GA) for acute liver injury induced by D-galactosamine(GalN) in rats.Methods Sixty rats were randomly divided into six groups.Except the negative control group,the other groups were intraperitoneally injected with 10% GalN 500 mg/kg.Three days prior to the GaIN treatment 18α-GA was intraperitoneally injected with 15,30,and 60 mg/kg once per day After 30 h of GalN treatment,serum ALT and AST were detected and the left lobes of the liver were histologically examined.Results 18α-GA could significantly inhibit the level of serum ALT and AST,and reduce the pathological damage in acute liver injury of the rats.Conclusion 18α-GA has the potential to prevent and treat acute liver injury induced by GalN in the rats.

Key concepts: Medicine, Galactosamine, Liver injury, Pathological, Gastroenterology, Internal medicine, Pharmacology, Biochemistry

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18α glycyrrhizic acid in the treatment of acute liver injury induced by D-galactosamine in rats — Research Paper | ScholarLens