The value of the Thinprep cytology test and high risk human papillomavirus testing in screening cervical epithelial lesions

Objective To analyze the difference the value of the ThinPrep cytology test(TCT) and high risk human papillomavirus(HR-HPV) testing in screening cervical epithelial lesions.Methods Specimens form 3723 women in Chaozhou city guangdong privence were tested by TCT and HR-HPV testing.The samples with TCT or HR HPV positive were examinated by histopathology of the cervical tissue.Furthermore,the effectiveness of TCT or HR-HPV testing and combining both were evaluated in cervical cancer screening.Results 78 cases were positive in TCT,ASC 15(19.2%) ;LSIL 44(56.4%) ;HSIL 19(20.2%).65 cases were positive in HR-HPV testing.Positive rate of HR HPV was 1.7%(65 /3723).Among 94 cases with histopathological diagnosis,19(20.2%) were inflammation,39(41.5%) CINⅠ,15(16.0%) CINⅡ,20(8.16%) CINⅢ,1(1.1%) SCC.The positive predictive value and negative predictive value were 0.45 and 0.94 respectly of TCT in cervical epithelial lesions screening,that were 0.52 and 0.93 in HR-HPV testing.The positive predictive value was 0.69 of TCT combined HR-HPV testing,which showed higher than TCT,and it was significant difference(χ2 = 7.290,P = 0.007),but was no difference with HR-HPV testing in screening of cervical epithelial lesions(χ2 = 3.386,P = 0.066).Conclusions TCT and HR-HPV testing are effective method in screening of cervical epithelial lesions.TCT combined HPV testing increase the positive predictive value in screening of cervical epithelial lesions.