Effects of Shugan Jianpi prescription on absorptive function of colon mucosa in rats with D-IBS induced by dopamine

[Objective] To investigate the effects of Shugan Jianpi prescription(SGJP) on the absorptive function of colon mucosa in rats with irritable bowel syndrome diarrhea predominant(D-IBS) induced by dopamine(DA).[Methods] Male Sprague-Dawley rats(200±20) g were randomly divided into three groups: normal group,D-IBS group and SGJP group.Short circuit current(Isc) technology was employed for detecting the change of short circuit current of colon mucosa in rats in vitro after modeling and treatment with SGJP.The influence of DA,norepinephrine(NE) and SGJP on the Isc of colon mucosa was observed.[Results] The basal current(BC) between D-IBS and normal group showed no significant difference(P0.05);compared to the normal group,the short circuit current change(△Isc) of D-IBS group was significantly reduced by NE(P0.05);the △Isc of SGJP group was significantly decreased after treatment with SGJP(P0.05).[Conclusion] Compared with the normal group,the absorptive function induced by DA in D-IBS group was significantly increased;SGJP could cure the D-IBS rats by improving this response.