Calcipotriol betam ethasone ointment and Halometasone Cream in the treatment of vitiligo vulgaris: a self-controlled,parallel group study

Objective To assess the clinical eficacy and safety of calcipotriol betam ethasone and halometasone cream in Chinese patients with stable vitiligo vulgaris.Methods In this self-controlled parallel group study.68 vitiligo with symmetrical white macules were recruited from the out-patient clinic.The left lesions receive alcipotriol betamethasone ointment once daily in the evening,and the right lesion receive halometasone cream once daily in the morning.The safety and eficacy of the two regimens were evaluated on week 12 after the first dosage.Results Atier 12 weeks of treatment,mean repigmentation was observed in 15.51% ±0.13%for the left lesions,12.86%±0.22% for the right group.There is significant difference between calcipotriol betam ethasone and halometasone cream(T=2.013,P0.05).The ratio of side-effects was 1.4%±0.02% in the calcipotriol betam ethasone group,and 2.9%±0.01% in the halometasone cream group.Significant difference is seen among the two groups(χ2=4.345,P0.05).Main side adverses include mild to moderate skin reactions,such as pruritus.Conclusions Once daily calcipotriol betamethasone ointment is an effective,safe,convenient treatment with a rapid onset of action for stable vitiligo vulgaris in Chinese patients.