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SNP 45(T/G) of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus

Lanjie He

Abstract

Objective To investigate the relation of single nucleotide polymorphisms (SNP)45T/G the adiponectin gene with type 2 diabetes of Han nationality in Ningxia.Methods PCR-RFLP method was used to identify the distribution of alleles and genotypes frequencies of SNP45T/G polymorphisms in adiponectin gene in 100 type 2 diabetic patients and 101 normal subjects.Results The distribution of genotypes and alleles frequencies of the SNP45 polymorphisms were significantly different (GG genotype:13% vs 3%,P0.05;G allele;76% vs 24%, P0.05).Conclusion SNP45 in adiponectin gene was related to type 2 diabetes of Han nationality in Ningxia. Individuals with SNP45 GG genotype of adiponectin gene have high susceptibility to type 2 diabetes.

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Key concepts: Adiponectin, Genotype, Single-nucleotide polymorphism, Allele, SNP, Genetics, Polymorphism (computer science), Type 2 diabetes