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2004•Acta Universitatis Medicinalis Secondae ShanghaiRequires access

Relationship between adiponectin gene polymorphisms and type 2 diabetes

Dong Yan

Open publisher page 6 citations

Abstract

Objective To test the association of single nucleotide polymorphisms (SNP)45T→G and SNP276G→T in the adiponectin gene with type 2 diabetes in Shanghai Han population. Methods For the case-control study, PCR-RFLP method was used to determine the distributions of allele and genotype frequencies of SNP45T→G polymorphism in exon 2 and SNP276G→T polymorphism in intron 2 in adiponectin gene in 195 type 2 diabetic patients and 187 normal control subjects. Results The distribution of genotype and allele frequencies of the SNP45 and SNP276 polymorphism were not different in diabetes and control groups(P0.05). There also was no difference in BMI between homozygous carries of the TG haplotype and heterozygous carries of the TG haplotype(TG/X) or noncarries(X/X) in diabetes and control groups(P0.05). Conclusion The results suggest that these two SNPs in adiponectin gene were not associated with type 2 diabetes in Shanghai Han population.

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What this paper is about

Objective To test the association of single nucleotide polymorphisms (SNP)45T→G and SNP276G→T in the adiponectin gene with type 2 diabetes in Shanghai Han population. Methods For the case-control study, PCR-RFLP method was used to determine the distributions of allele and genotype frequencies of SNP45T→G polymorphism in exon 2 and SNP276G→T polymorphism in intron 2 in adiponectin gene in 195 type 2 diabetic patients and 187 normal control subjects. Results The distribution of genotype and allele frequencies of the SNP45 and SNP276 polymorphism were not different in diabetes and control groups(P0.05). There also was no difference in BMI between homozygous carries of the TG haplotype and heterozygous carries of the TG haplotype(TG/X) or noncarries(X/X) in diabetes and control groups(P0.05). Conclusion The results suggest that these two SNPs in adiponectin gene were not associated with type 2 diabetes in Shanghai Han population.

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Available abstract

Objective To test the association of single nucleotide polymorphisms (SNP)45T→G and SNP276G→T in the adiponectin gene with type 2 diabetes in Shanghai Han population. Methods For the case-control study, PCR-RFLP method was used to determine the distributions of allele and genotype frequencies of SNP45T→G polymorphism in exon 2 and SNP276G→T polymorphism in intron 2 in adiponectin gene in 195 type 2 diabetic patients and 187 normal control subjects. Results The distribution of genotype and allele frequencies of the SNP45 and SNP276 polymorphism were not different in diabetes and control groups(P0.05). There also was no difference in BMI between homozygous carries of the TG haplotype and heterozygous carries of the TG haplotype(TG/X) or noncarries(X/X) in diabetes and control groups(P0.05). Conclusion The results suggest that these two SNPs in adiponectin gene were not associated with type 2 diabetes in Shanghai Han population.

Key concepts: Genotype, Haplotype, Adiponectin, Single-nucleotide polymorphism, Allele, Type 2 diabetes, Polymorphism (computer science), SNP

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