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2010•Shandong yiyaoRequires access

Studies on adiponectin gene polymorphisms in patients with metabolic syndrome

Hui‐Jun Mu

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Abstract

Objective To investigate the association of single nucleotide polymorphisms(SNP)45 T→G and SNP276 G→T in the adiponectin gene with metabolic syndrome(MS).Methods 183 patients with MS and 144 participants were selected.Adiponectin gene SNP45 of them were analyzed by TaqMan technology.Adiponectin gene SNP276 of them were analysised by direct sequencing.Results The distributions of SNP45 genotypes were different between MS and the control group(P0.05).The analysis of allele frequency showed the major allele was G in MS patients(P0.05).The subjects with SNP45 TG or GG genotype had lower serum adiponectin levels than those with TT genotype in MS groups(P0.05).The distribution of genotype and allele frequencies of SNP276 were not different in MS and control groups(P0.05).Conclusion SNP45 G/G genotype seems to be the susceptive gene in MS patients of Chinese Han.

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What this paper is about

Objective To investigate the association of single nucleotide polymorphisms(SNP)45 T→G and SNP276 G→T in the adiponectin gene with metabolic syndrome(MS).Methods 183 patients with MS and 144 participants were selected.Adiponectin gene SNP45 of them were analyzed by TaqMan technology.Adiponectin gene SNP276 of them were analysised by direct sequencing.Results The distributions of SNP45 genotypes were different between MS and the control group(P0.05).The analysis of allele frequency showed the major allele was G in MS patients(P0.05).The subjects with SNP45 TG or GG genotype had lower serum adiponectin levels than those with TT genotype in MS groups(P0.05).The distribution of genotype and allele frequencies of SNP276 were not different in MS and control groups(P0.05).Conclusion SNP45 G/G genotype seems to be the susceptive gene in MS patients of Chinese Han.

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Available abstract

Objective To investigate the association of single nucleotide polymorphisms(SNP)45 T→G and SNP276 G→T in the adiponectin gene with metabolic syndrome(MS).Methods 183 patients with MS and 144 participants were selected.Adiponectin gene SNP45 of them were analyzed by TaqMan technology.Adiponectin gene SNP276 of them were analysised by direct sequencing.Results The distributions of SNP45 genotypes were different between MS and the control group(P0.05).The analysis of allele frequency showed the major allele was G in MS patients(P0.05).The subjects with SNP45 TG or GG genotype had lower serum adiponectin levels than those with TT genotype in MS groups(P0.05).The distribution of genotype and allele frequencies of SNP276 were not different in MS and control groups(P0.05).Conclusion SNP45 G/G genotype seems to be the susceptive gene in MS patients of Chinese Han.

Key concepts: Adiponectin, Genotype, Single-nucleotide polymorphism, Allele, TaqMan, SNP, Allele frequency, Gene

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