Relationship between adiponectin gene single nucleotide polymorphism and Atherosclerosis

Objective:To investigate the relationship between adiponectin gene single nucleotide polymorphisms(SNPs) and atherosclerosis in the Taizhou population.Methods: By using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) analysis,198 AS patients and 68 controls were characterized for adiponectin gene polymorphisms (-11377C/G,and +276G/T).Results: The frequency of adiponectin gene SNP+276TT genotype and T allele were significantly lower in patients of AS than controls.There was no significant difference in adiponectin-11377C/G SNP genotype among each group,The frequency of SNP-11377 C allele were significantly lower in patients of AS than controls.There was significant difference in C reactive protein,triglyeride(TG),total cholesterol(TC),low-density lipoprotein(LDL-c) and glucose(Glu) between adiponectin SNP+276TT genotype and SNP+276GT+GG.Conclusion: SNP276 polymorphism of adiponectin gene is associated with AS in the population of Han ethnicity in Taizhou.The risk of AS increases in GG or GT genotype compared to TT genotype.The G allele may be a risk factor of AS in Han ethnicity of China.