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The changes of MDA levels and SOD activity in retinal tissue after severe alkali burn of cornea in rats

Chen Xiang-hu

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Abstract

Objective To study the changes of MDA levels and SOD activity in retinal tissue after severe corneal alkali burn. Methods 41 healthy Wistar rats were randomly divided into 2 groups: experimental and control groups.A model of severe corneal alkali burn was established in both eyes of 35 Wistar rats with 1 mol/L NaOH solution for 30 seconds.Six rats were executed respectively on the 1st,3rd,7th,15th,and 30th day after the burning,and both eyes were enucleated.Retinal histologic homogenate was made for detection of MDA and SOD. Results MDA increased gradually from 1 to 7 days after severe alkali burn of cornea in rats,and then dropped gradually.SOD decreased gradually from 1 to 7 days,and then increased gradually. Conclusions Lipid peroxidation existed in the retina after severe alkali burn of cornea in rats,which may aggravate the damage to the retina.

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What this paper is about

Objective To study the changes of MDA levels and SOD activity in retinal tissue after severe corneal alkali burn. Methods 41 healthy Wistar rats were randomly divided into 2 groups: experimental and control groups.A model of severe corneal alkali burn was established in both eyes of 35 Wistar rats with 1 mol/L NaOH solution for 30 seconds.Six rats were executed respectively on the 1st,3rd,7th,15th,and 30th day after the burning,and both eyes were enucleated.Retinal histologic homogenate was made for detection of MDA and SOD. Results MDA increased gradually from 1 to 7 days after severe alkali burn of cornea in rats,and then dropped gradually.SOD decreased gradually from 1 to 7 days,and then increased gradually. Conclusions Lipid peroxidation existed in the retina after severe alkali burn of cornea in rats,which may aggravate the damage to the retina.

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Available abstract

Objective To study the changes of MDA levels and SOD activity in retinal tissue after severe corneal alkali burn. Methods 41 healthy Wistar rats were randomly divided into 2 groups: experimental and control groups.A model of severe corneal alkali burn was established in both eyes of 35 Wistar rats with 1 mol/L NaOH solution for 30 seconds.Six rats were executed respectively on the 1st,3rd,7th,15th,and 30th day after the burning,and both eyes were enucleated.Retinal histologic homogenate was made for detection of MDA and SOD. Results MDA increased gradually from 1 to 7 days after severe alkali burn of cornea in rats,and then dropped gradually.SOD decreased gradually from 1 to 7 days,and then increased gradually. Conclusions Lipid peroxidation existed in the retina after severe alkali burn of cornea in rats,which may aggravate the damage to the retina.

Key concepts: Cornea, Ophthalmology, Retina, Retinal, Lipid peroxidation, Medicine, Chemistry, Internal medicine

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The changes of MDA levels and SOD activity in retinal tissue after severe alkali burn of cornea in rats — Research Paper | ScholarLens