Chemiluminesent immunoassay determined the level of serum testosterone in men with coronary heart disease andits clinical significance

Objective To determine the level of serum sex hormone in male with coronary heart disease(CHD) and observe its clinical significance.Methods 115 men underwent coronary angiography were distributed into CHD group and control group.The severity of coronary artery lesion was evaluated by cumulative scores of lesion.The serum testosterone(T) and estradiol(E2) were examined by the Chemiluminesent immunoassay.Results (1)Men with CHD had significantly lower level of serum T(t=3.15,P0.01) than control group.Excluding the patients with DM,the level of T between two groups still had obvious difference after controlling for age,BMI and LDL-C(F=6.11,P0.01).(2)The level of T was negatively correlated with the scores of lesion,age,BMI (r=-0.28,P0.01;r=-0.24,P=0.01;r=-0.26,P0.05).(3)Logistic analysis show low serum T level,age and high TC were risk factors of male CHD.Conclusions (1)The male patients with CHD had significantly lower serum T level.(2)The serum T level was negatively correlated with the degree of coronary artery lesion,age,BMI.(3)A low serum T level may be a risk factor for male CHD.