Drug resistance of gram-negative bacilli in this hospitail in 2006

Objective To investigate the distribution and drug resistance of gram-negative bacilli in clinical specimens in 2006,helping rationaluse of antibiotic in clinical practice.Methods Antrimicrobial susceptibility tests were done on 744 strains of gram-negative bacilli isolated by Kirby-Bauer method,the detection of ESBLs(extended-spectrum β-lactamases)-producing strains was performed for screening and confirming the presence of ESBLs.Results The majority of isolated gram-negative bacilli was Escherichia coli(39.0%),Pseudomonas aeruginosa(21.5%),and Klebsiella pneumoniae(17.3%).The susceptibilities of these strains to 12 antibiotic were different.Imipenem was the most active antimicrobias against gram-negative bacilli;cefoperazone/sulbactam and piperacillin/tazobactam also showed excellent activity.Their susceptibility was remarkably lower than that of ESBLs negative strains.Conclusions Drug resistance of gram-negative bacilli is high and multiple.It is important to detect ESBLs in clinical laboratory,helping rational use of antibiotics in clinical practice.