Therapeutic Effects of Montelukast Combined with Budesonide Inhalation on Children with Moderate to Severe Asthma

Objective:To observe the clinical effect of montelukast combined budesonide inhalation therapy on children with moderate to severe asthma.Methods:Forty five cases of children with moderate to severe asthma weren' t in acute episode period,the observation group of 20 cases received montelukast combined with budesonide (inhalation aerosol 100～200 μg/d),while the control group of 25 cases only budesonide (inhalation aerosol 400～600 μg/d),for more than 3 months of treatment.Records of asthma symptom score,acute attack frequency and demand for quick β_2-agonist inhalation were made.Results:Of the observation group daytime asthma score,nighttime score,acute attack frequency and demand for inhaled β_2-receptor agonists,respectively was (0.1±0.31),(0.15±0.37), (0.2±0.37) times,(0.75±0.64) sprays,while of the control group was(1.52 ±0.87),(1.56 ±0.77),(1.84 ±1.28) times, (2.68±1.11) sprays.Between the both groups the differences were statistically significant (P0.05).Conclusions:Oral montelukast combined with budesonide inhalation in children can significantly improve the clinical efficacy of moderate to severe asthma.