Changes of immunologic function in children with recurrent respiratory tract infection before and after treatment with intravenous gamma globulin

Objective To study the changes of immunologic function in children with recurrent respiratory tract infection before and after treatment with intravenous gamma globulin.Methods The CD 3,CD 4,CD 8 cells of the children with recurrent respiratory tract infection before and after(7d,30d) treatment with intravenous gamma globulin were detected by means of T cell subgroup SAP method.The IgA,IgM,IgG,C 3 were detected by means of immunization turbidimetry.In order to observe the changes of immunologic function in children with recurrent respiratory tract infection,28 normal infants and young children were selected as control group.Results The levels of CD 3,CD 4,CD 4/CD 8,IgA,IgG,IgM of the children with recurrent respiratory tract infection were lower than that in control group.The CD 3,CD 4,CD 8,CD 4/CD 8,C 3,IgA showed little variation in childhood patients who treated with intravenous gamma globulin for 1 week(P0.05).CD 4,CD 4/CD 8 of the childhood patients decreased after medication for 1 month(P0.05).IgA,IgG,IgM were lower than that before medication(P0.05).Conclusion Intravenous gamma globulin could not be used to against recurrent respiratory tract infection,moreover,it would affect immunologic function of organism.