Effect of Irbesartan and Hydrochlorothiazide on Blood Pressure in Patients with Essential Hypertension and Left Ventricular Hypertrophy

Objective To observe the reversal effect of irbesartan and hydrochlorothiazide on blood pressure in patients with essential hypertension and left ventricular hypertrophy.Methods 56 cases of essential hypertension with left ventricular hypertrophy were randomly divided into two groups,treated with irbesartan 150 mg/d,plus hydrogenation chlorothiazide 12.5 mg/d in the observation group,for 6 months,observed before and after treatment of blood pressure change and calculate left ventricular myocardial weight measurement(LVM),left ventricular mass index(LVMI).Results The two groups after treatment compared with those before treatment significantly reduced SBP and DBP,and the observation group was lower than the control group after treatment(P﹤0.05).LVM,LVMI were significantly lower in both groups of patients after treatment,and the observation group was lower than the control group(P﹤0.05).No significant difference was observed in serum potassium levels after treatment(P﹥0.05).Conclusion Irbesartan combined with hydrochlorothiazide effect on lowering the blood pressure and reversing of left ventricular hypertrophy is better than the single-use.