Therapeutic Effects of Irbesartan on Reversing Left Ventricular Hypertrophy in Patients with Essential Hypertension

Objective To observe the therapeutic effects and security of lrbesartan on reversing left ventricular hypertrophy in patients with essential hypertension.Methods 90 patients with essential hypertension concomitant with left ventricular hypertrophy were randomly divided into two groups:therapeutic group(45 cases) and control group(45 cases).The therapeutic group was treated with lrbesartan(150~300 mg/d,qd) and the control group was treated with captopril(25~50 mg,tid) for 6 months.The blood pressure(Bp),echocardiographic changes,routine blood,urine and excrement,the function of liver and kidney were observed before and after treatment.Results The Bp of two groups were all decreased significantly after treatment(P0.01),but there were no significant differences between two groups(P0.05).The left ventricular hypertrophy was all significantly reversed after treatment(P0.05),but there were no significant differences between two groups(P0.05).The incidence of adverse reaction of the therapeutic and control group were 2.2% and 15.5% respectively. Conclusion Irbesartan and captopril can all decrease Bp and reverse left ventricular hypertrophy,but Irbesartan has little adverse effect which is easy to be tolerant.