Pharmacokinetics of Florfenicol in Pigs

The pharmacokinetics of florfenicol was investigated in 6 healthy pigs.The plasma concentrations of florfenicol were determined by HPLC with UV detection at 223 nm.The plasma concentration time data derived from experiments were analyzed by non compartmental method based on statistical moment theory.The main pharmacokinetic parameters after intravenous administration were as follows:AUC 90.13 mg/(L·h),MRT 6.84 h,Cl B 0.23 L/(kg·h),Vd (SS) 1.53 L/kg,t 1/2β 6.72 h.The main pharmacokinetic parameters after intramuscular administration were:AUC 84.13 mg/(L·h),MRT 26.88 h,t 1/2β 17.18 h,F 96.86%,F * 42.50%.The main pharmacokinetic parameters following oral administration were:AUC 132.08 mg/(L·h),MRT 14.23 h,t 1/2β 9.98 h,F 148.53%,F * 108 51%.The pharmacokinetic characteristics of florfenicol after intravenous administration were large apparent distribution volume,wide distribution in the body,and high plasma level.After intramuscular administration of florfenicol in pigs,the absorption was irregular and retarded,and the elimination from the body was slow.The absorption of drug was complete and bioavailability value was high after oral administration.