Comparative pharmacokinetics of florfenicol granule and florfenicol powder in pigs.

Fourteen healthy pigs were divided into two groups of 7 pigs each.The pigs in group A were orally administrated with single dose of florfenicol powder at 30 mg/kg.The pigs in group B were also orally administrated with single dose of florfenicol granule at 30 mg/kg.Comparative study on the pharmacokinetics of florfenicol powder and florfenicol granule was carried out.Plasma concentration of florfenicol was determined by HPLC.The concentration-time data of florfenicol were analyzed by non-compartmental model based on pharmacokinetic software WinNonlin 5.2.1.The main pharmacokinetic parameters of powder following oral administration were: t1/2β =(10.22±0.18) h,ke =(0.07±0.01) h-1,tmax =(1.67±0.48) h,Cmax=(24.68±1.13) μg·mL-1,AUC=(190.97±16.60) μg·mL-1·h,MRT=(8.33±0.42) h,tcp=(17.66±1.52) h.The main pharmacokinetic parameters of granule following oral administration were : t1/2β =(16.36±4.14) h,ke=(0.05±0.01) h-1,tmax=(5.71±0.47) h,Cmax=(12.23±0.78) μg·mL-1,AUC=(155.44±6.59) mg·mL-1·h,MRT=(14.96±0.35) h,tcp=(23.03±0.49) h.The results showed the granule of florfenicol after oral administration had slower elimination and longer effective time of the blood medicine density maintenance.