Klebsiella pneumoniae in Lower Respiratory Infection:Drug Resistance Analysis of 45 Strains

OBJECTIVE To study the frequency and the drug resistance of ESBLs producing Klebsiella pneumoniae, and prevent the outbreak of hospital infection. METHODS The clinical data of inpatients infected by K. pneumoniae in lower respitatory tract from Mar 2003 to Jun 2004 were retrospectively analyzed. RESULTS The total detected rate of bacteria with ESBLs was 55 6%, and the distribution mainly was in departments of neurosurgery, neurology and thoracosurgery. The susceptivity of ESBLs producing was 95 5% for imipenem/cilastatin, and 41 7% for piperacillin/tazobactam, but the drug resistant rate was 70 4 100 0% for other 16 antibiotics in bacteria. The drug resistant rate in ESBLs nonproducing bacteria was 93 3% for ampicillin and 6 7 44 4% for other 15 antibiotic drugs. CONCLUSIONS The reasonable usage of antibiotics and strictly sterilizing isolating rules are very important for reducing the rate of ESBLs producing bacteria and preventing the ourbreak of hospital infection.