Drug resistance of klebsiella pneumoniae in geriatric hospital in Shaoxing in recent two years

OBJECTIVE To collect of Klebsiella pneumoniae in geriatric hospital in Shaoxing from Jan 2008 to Oct 2009,to understand the distribution and drug resistance,to provide the clinical basis for the rational use of antimicrobial agents.METHODS Drug susceptibility test was performed by micro-dilution method,extended spectrum β-lactamases(ESBLs)-producing bacteria were detected by disk confirmation test.RESULTS MostK.pneumoniae isolates were collected from sputum and urine specimens.The department of respiratory,ICU and elderly wards were the most common.ESBLs K.pneumoniae accounted for 40.3%,the strains to imipenem and meropenem 100.0% sensitive to amoxicillin,ticarcillin,cefuroxime,Cefalotin was 100.0% resistant to other antibiotics with higher resistance;The drug resistance of 117 ESBLs-negative bacteria to antimicrobial agents was low,and compared with 79 ESBLs-positive bacteria,the difference was statistically significant(P0.01).CONCLUSION Court ESBLs producing K.pneumoniae resistance to serious,should be strengthened K.pneumoniae occurrence of ESBLs and their antimicrobial resistance detection and monitoring,prevention of drug-resistant strains of the epidemic.