Nosocomial Infection and Drug Resistance of Klebsiella Pneumonia

Objective To investigate the characteristics of nosocomiai infection of Klebsiella pneumonia(K.pneumonia)and its drug resistance,and to provide scientific evidence for clinical reasonable usage of antibiotics.Method We analyzed retrospectively the source of specimen and its infection distribution of 199 patients with K.pneumonia,the detection rate of ESBLs producing strains,drug resistance of producing and Non-producing strains of ESBLs.Results 199 strains of K.pneumoniae were mostly from the sputum,accountting for 60.30%.Infection caused by K.pneumoniae were frequently occurred in Intensive care units(ICU 28.14%)and Department of respiratory(26.63%),ESBLs producing strains showed multi-drug resistance,The resistant rates of ESBLs producing strains to Cephalosporins,Penicillins,Aminoglycosides,Quinolones were very high,there was a significant(P0.01)relationship between producing and Non-producing strains of ESBLs.Conclusions ESBLs producing strains of K.pneumoniae have multi-drug resistance apparently.Besides,non-ESBLs-producing strains of K.pneumoniae have higher sensitivity to Imipenem.Rational usage of antibacterial drugs can reduce hospital infections.