Study on drug resistance of klebsiella pneumoniae pneumonia

Objective To determine the antibiotic resistance and the productive rate of extended-spectrum-beta-lactamase (ESBLs) of Klebsiella pneumoniae pneumonia.Methods One hundred eighteen strains of Klebsiella pneumoniae were isolated from Klebsiella pneumoniae pneumonia patients admitted to the Shenzhen Armed Police Hospital during 1999 to 2002,then antibiotic susceptibility test was peformed by Kirby-Baucer disk diffusion assay.ESBLs production was performed by the standard disk diffusion method.Results ESBLs productive rate was 35% from Klebsiella pneumoniae pneumonia patients.ESBLs-producing strains had higher drug-resistance than No-ESBLs-producing strains.ESBLs-producing strains were only sensitive to the combination of third-generation cephalosporins and beta-lactase inhibitor,fourth-generation cephalosporins and imipenem.Imipenem had the most effective antibiotic activity among them.ESBLs-producing strains infection was the main lethal cause of Klebsiella pneumoniae pneumonia.Conclusion ESBLs production of Klebsiella pneumoniae pneumonia had significantly increased.ESBLs-producing strains was most senstive to Imipenem.ESBLs-producing strains infection was the main lethal cause.Measures should be taken to control the infection of ESBLs-producing strains.