Haemodynamic characteristics of normal human pancreas and pancreatic carcinoma evaluated with multi-slice CT dynamic perfusion technique

AIM: To evaluate and analyze the haemodynamics of normal pancreas and pancreatic carcinoma quantitatively with multi-slice CT (MSCT) perfusion imaging software. METHODS: ①Thirty normal controls and twenty pancreatic carcinoma patients were selected from Nanfang Hospital of Southern Medical University from January 2005 to December 2006.②GE Lightspeed 16-row CT was used to perform dynamic perfusion in all the subjects, with scanning parameters of 120 kV, 60 mA, 5-mm thick × 4 layers, matrix 512×512, 1 frame/s. Before scanning, 20-G detaining pin was embedded into elbow vein, injecting 50 mL (300 mg I per milliliter) non-ionic contrast medium with high-pressure syringe, at the velocity of 4.0 mL/s, 6 seconds delaying, for totally 60 seconds.③The measured value included time to peak (TTP), peak value (PV), blood flow (BF), blood volume (BV), mean transit time (MTT), and vascular permeability-surface (PS). Data were collected and analyzed with perfusion-3 software pack in GE AW4.2 station. RESULTS: All of 50 subjects were involved in the result analysis.①Compared with control group, the TTP was prolonged [(27.75±9.87), (22.12±4.26) s, P 0.05], and PV was shortened in pancreatic carcinoma group [(23.12±7.03), (69.47±14.46) Hu, P 0.01].②BF and BV were significantly lower in pancreatic carcinoma group than in control group (P 0.01), while MTT and PS were larger than those in control group (P 0.01). CONCLUSION: ①The MSCT dynamic perfusion technique has a kind of utility within clinical applications in terms of pancreatic carcinoma qualitative diagnosis.②As for pancreatic carcinoma group, BF and BV sharply decrease, PV and PS degrade, TTP and MTT dramatically extend.