Study of pancreatic carcinoma with multislice CT perfusion imaging

Objective To investigate the perfusion characteristics of normal pancreas and pancreatic carcinoma on multi-slice spiral CT(MSCT).Methods Perfusion CT for pancreatic cancer was performed with sixteen-slice spiral CT in 26 patients(all of them were then confirmed by pathology).Eighteen patients without pancreatic disorders served as controls.Contrast medium-enhanced dynamic CT was performed,and the data were analyzed by using commercial software to calculate tissue blood flow(BF),blood volume(BV),mean transit time(MTT),and vascular permeability-surface(PS)area product.Perfusion parameters of normal pancreas and tumors tissues were compared.Results Technical failures were experienced in 1(3.85%)subjects of pancreatic carcinoma.The mean BF,BV,MTT and PS in pancreatic carcinoma were(68.89±73.42)mL/(100 mg· min),(10.02±3.59)mL/100 mg,(8.23±3.26)s,(28.63±9.35)mL/(100 mg·min),respectively.The mean BF,BV,MTT and PS in normal pancreas tissue were(173.53±71.33)mL/(100 mg·min),(14.43±3.15)mL/100 mg,(7.15±5.45)s,(13.98±8.53)mL/(100 mg·min),respectively.The mean BF,BV and PS between pancreatic carcinoma and normal pancreas were statistically significant(BF,PS:P0.01;BV:P0.05).However,the mean MTT between pancreatic carcinoma and normal pancreas was not statistically significant(P0.05).Conclusion CT perfusion imaging can be used to identify patients with pancreatic carcinomas,because individual differences exist in the results of CT perfusion.