Clinical observation of irbesartan combined with hydrochlorothiazide in treatment of elderly patients with primary hypertension

Objective To observe the efficacy of irbesartan combined with hydrochlorothiazide in the treatment of elderly patients with primary hypertension. Methods Eighty elderly patients with primary hypertension who were treated and hospitalized in our hospital from January 2012 to January 2013 were selected as the study subjects and randomly divided into the observation group and the control group, with 40 patients in each group. The control group was given irbesartan and the observation group was given irbesartan combined with hydrochlorothiazide. The efficacy of the two groups was observed and the blood pressure change between before and after treatment and the adverse reactions during medication were recorded. Results The total effective rate of the observation group was 95.00% and that of the control group was 75.00%, with statistically significant difference in the efficacy between the two groups(P 0.05). In the observation group, the post-treatment SBP reached(123.82±14.18)mm Hg and DBP(85.18±12.37)mm Hg, which were significantly different from the post-treatment SBP and DBP of the control group respectively(P 0.05). Conclusion In the treatment of elderly patients with primary hypertension, irbesartan combined with hydrochlorothiazide shows accurate efficacy, can obviously reduce the patients' systolic pressure and diastolic pressure, and causes no obvious adverse reactions, thereby worthy of promotion and application.