Analysis of Pathogenic Bacteria in Children with Urinary Tract Infection

Objective To investigate the distribution and drug-resistance of pathogenic bacteria in children with urinary tract infection, so as to provide theoretical basis of diagnoses and treatment. Method The positive results of urine culture of 393 children with urinary tract infections in outpatients and inpatients from Jan 2004 to Aug2008 were analyzed. Results A total of 427 stains were isolated. Among 427 pathogens,the majority which occupied71.5 percents was gram- negative bacteria,and the most of it was Escherichia coli which occupied 58.5 percents;then gram- positive bacteria occupied 24.9 percents,in which Enterococcus accounted for 10.9 percents; besides,fungi occupied 3.6 percents. Antibiotic susceptibility test revealed a high prevalence(50%) of resistance to penicillin,erythromycin,ampicillin,cotrimoxazole,gentamicin and cefazolin, oxacillin. higher.Susceptibility to amikacin and ciprofloxacin was above 50%. Imipenem- cilastatin appeared to be the most effective antibiotic against bacterium isolated from this sample. Nitrofurantoin was effective for both gram negative and gram positive germs. Vaneomycin was the most effective antibiotics against Cocci. Conclusion Gram- negative bacteria is predominant in pathogens of Urinary tract infection in children. E.coli is the commonest causative bacteria. But gram- positive bacteria, especially enterococcus should be paid attention to. Ampicillin, cotrimoxazole,gentamicin and cefazolin is not the adequate selection for treating urinary tract infection. The third generation cephalosporinsand may be recommended as the first selection for urinary tract infection.Amikacin and ciprofloxacin could be used for some older children. Imipenem- cilastatin,vaneomycin may also be used for the serious patients with urinary tract infection, which should be used reasonably according to results of antibiotic susceptibility.