Analysis of Causing Bacterial Profile and Resistance to Antibiotics in Children with Urinary Tract Infection

Objective To investigate bacterial distribution and resistance status in children with urinary tract infection. Methods A total of 114 strains of bacterium isolated from 102 hospitalized patients with urinary tract infection were identified and test of antibiotic resistance was performed from Jan 2000 to Dec 2004. Results The urinary tract infection was mainly caused by E.Coil(65.79%),followed by Klebsiella pneumoniae(6.14%),Enterococcus faecalis(4.39%),Proteus mirabilis(3.51%) and Enterococcus faecium(3.51%).Gram positive bacterium,especially Enterococcus specie was increased.Antibiotic susceptibility test revealed a high prevalence of resistance to ampicillin(50%),cotrimoxazole,gentamicin and cefazolin.Susceptibility to the second,third and fourth generation cephalosporins was relatively higher.Susceptibility to amikacin and ciprofloxacin was above 50%.Imipenem-cilastatin appeared to be the most effective antibiotic against bacterium isolated from this sample.Nitrofurantoin was effective for both gram negitive and gram positive germs.Vaneomycin was the most effective antibiotics against cocci. Conclusion E.coli is the commonest causative bacteria in urinary tract infection in children.Ampicillin,cotrimoxazole,gentamicin and cefazolin is not the adequate selection for treating urinary tract infection.However,third generation cephalosporinsand,and nitrofurantoin may be recommended as the first selection for urinary tract infection.Imipenem-cilastatin,vaneomycin,amikacin and ciprofloxacin may also be used for the serious patients with urinary tract infection.