Correlation between E-selectin A128C gene polymorphism and coronary heart disease

AIM To study the correlation between E-selectin gene polymorphism in exon 4 codon 128 and coronary heart disease(CHD) in Chinese Han population and the possibility of using the gene type to screen the susceptible and high-risk CHD population.METHODS The genotypes of E-selectin were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 145 CHD cases,including 73 with acute coronary syndrome(ACS) patients and 72 cases with stable coronary heart disease(SCHD),and 144 controls. RESULTS There was significant difference in the frequencies of genotype and allete in A/C polymorphism between CHD and control group,and between ACS and SCHD respectively(P0.01 and P0.05).The relative CHD risk in those with genotype CC+AC was 5.843 times that in those with genotype AA(OR=5.843,95%CI: 3.066-11.133).CONCLUSION E-selectin gene A/C polymorphyism is significantly associated with the occurrence,development and severity of CHD.C allele of E-selectin may be a genetic factor that may determine an individual′s susceptibility to CHD.