The study of intercellular adhesion molecule-1 gene polymorphisms C469T in patients with coronary heart disease

Objective:To explore whether ICAM-1 gene single nucleotide polymorphisms C/T in exon 6 codon 469 related to CHD in Chinese Han peoples of Hubei province. To study the correlation between the different genotypes. Method:The genotypes of ICAM-1 were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods in 145 CHD including 73 ACS patients and 72 SCHD patients, and 144 controls. Result:There was significant difference in frequencies of allele in C469T polymorphism between CHD and control group as well as ACS and SCHD respectively (CHD and control group: χ~2=20.254, P0.001; ACS and SCHD: χ~2=3.981, P0.05). The relative risk suffering from CHD with genotype TT+CT was 5.288 times of those with genotype CC (OR=5.288,95%;CI:2.977~9.395). Conclusion: ICAM-1 gene polymorphyism C469T is significantly associated with the CHD. T allele of ICAM-1 may be a genetic factor that may determine an individual's susceptibility for CHD.