2013•Zhongguo yiyuan ganranxue zazhiRequires access
Efficacy and safety of clotrimazole and nystatin suppository in treatment of vulvovaginal candidiasis during pregnancy
WU Xiong-jun
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Abstract
OBJECTIVE To observe and compare the efficacy and safety of clotrimazole and nystatin suppository in treatment of vulvovaginal candidiasis during pregnancy so as to provide basis for the treatment of vulvovaginal candidiasis during pregnancy.METHODS A total of 124 patients with pregnancy vulvovaginal candidiasis,who enrolled the hospital from Jun 2008 to Mar,were selected and randomly divided into the observation group and the control group with 62 cases in each;the observation group was treated with clotrimazole,the control group with nystatin suppository.The efficacy and safety of medication of the two groups were observed.RESULTS The VVC score of the observation group was obviously higher than that of the control group(P0.05).The cure rate of the observation group was 59.68%,significantly higher than 50% of the control group(P0.05).The inefficiency of the observation group was 1.61%,significantly lower than 6.45% of the control group(P0.05);the total effective rate of the observation group was 87.10%,significantly higher than 79.03% of the control group(P0.05).CONCLUSION The efficacy of clotrimazole is superior to that of nystatin suppository in treatment of pregnancy vulvovaginal candidiasis,and the safety of both two drugs is good.