Effect of Bushen Huoxue Recipe Series on Expression of bFGF mRNA in Brain Tissue of Vascular Dementia Mice

Objective To probe the effect of Bushen Recipe,Huoxue Recipe,and Bushen Huoxue Recipe on abilities of learning and memory as well as the expression of basic fibroblast growth factor(bFGF) mRNA in brain issue of vascular dementia mice.Methods We established the mice model of vascular dementia through the operation of cerebral ischemia reperfusion,observed the praxiological changes by the means of water maze,and examined the content of bFGF and the expression of bFGF mRNA in brain tissue in mice after treated with Bushen Recipe,Huoxue Recipe,and Bushen Huoxue Recipe,respectively.Results Compared with the sham operation group,the ability of learning and memory reduced in the model group,which was characterized with the prolongation of time for swimming the whole process and the increase of times of error(P 0.01),and the content of bFGF and the expression of bFGF mRNA in brain issue was increased(P 0.05 or P 0.01).Compared with model group,the learning and memorizing performance scores were improved(P 0.05 or P 0.01),and the content of bFGF and the expression of bFGF mRNA were increased(P 0.01) in brain tissue of each treatment group.The learning and memorizing performance scores of Bushen Huoxue Recipe group were superior to those in the other two treatment groups(P 0.05),and the contents of bFGF and the expression of bFGF mRNA in brain issue were superior to that in Huoxue Recipe(P 0.05) but had no different significant with Bushen Recipe group(P 0.05).Conclusion Bushen Recipe,Huoxue Recipe,and Bushen Huoxue Recipe all could increase the content of bFGF and improve the learning and memory abilities through promoting the expression of bFGF mRNA.The improvement of the learning and memory by Bushen Huoxue Recipe is superior to that of Bushen Recipe and Huoxue Recipe,and its regulation of bFGF content and bFGF mRNA expression is superior to that of Huoxue Recipe.