Effects of series prescription of Bushen Huoxue on the contents of IL-1β and TNF-α in brain issue of vascular dementia mice

Objective: To discuss the effect of Bushenfang,Huoxuefang,and Bushen Huoxuefang on ability of learning and memory,and the content of Interleukin 1β(IL-1β) and Tumor necrosis factorα(TNF-α) in brain tissue of vascular dementia mouse.Methods: To reproduce the mice model of vascular dementia through operation of cerebral ischemia reperfusion,and observe the mice behavior changes by the means of water morris and the contents of IL-1β and TNF-α in brain issue of Bushenfang,Huoxuefang,and Bushen Huoxuefang group.Results: Compared with sham operation group,the ability of vascular dementia model mice of learning and memory reduced(P0.01),and the contents of IL-1β and TNF-α was increased(P0.01).Compared with model group,the learning and memorizing performance record were improved(P0.05,P0.01) and the contents of IL-1β and TNF-α were decreased(P0.05,P0.01) in each treatment group;the learning and memorizing performance record of the Bushen Huoxue group were more excellent than other treatment groups(P0.05),and the contents of IL-1β and TNF-α of the group were decreased than other treatment group(P0.05,P0.01).Conclusion: The Bushen Huoxue series medicines could decrease the contents of IL-1β and TNF-α,and improve the learning and memory capability,and the Bushen Huoxue group were excellent than Bushenfang and Huoxuefang,and there is no different between the Bushenfang and Huoxuefang.