2003•Zhongguo gushangRequires access
Effect of Bushen Jianpi Huoxue recipe on expression of TNF-α in bone tissue of ovariectomiced rats
Yang Cao
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Abstract
Objective To observe the effect of Bushen Jianpi Huoxue recipe on the expression of TNF-α in bone tissue of rat postmenopausal osteoporasis model Methods 84 female rats were divided to 7 groups: normal group,sham operation group,model group, Chinese herb control group, western medicine control group, large dose of Bushen Jianpi Huoxue recipe group and small dose of Bushen Jianpi Huoxue recipe group. The rat 's postmenopausal osteoporosis model was made by ovariectomy 90 days after treatment, the expression of TNF-α in bone tissue were be detected. Results Bushen Jianpi Huoxue recipe can decrease the number of TNF-α positive expression cells. The effect of large dose group is superior to small dose Chinese herb control group and western medicine control group. Conclusion The effectiveness of treatment with Bushen Jianpi Huoxue recipe can decrease bone absorption by passing through effecting of the expression of TNF-α.