Comparative study of laparoscopic surgery and laparotomy for gastric cancer on blood coagulation

Objective:To investigate the difference of laparoscopic surgery and laparotomy for gastric cancer on blood coagulation.Methods:Blood coagulation was determined by detecting the values of the PT,APTT,FIB and INR,and enzyme linked immunosorbent assay(ELISA)was used to detect the value of D-D at pre-operation,post-operation and 24th hour after operation in 35 patients under laparoscopic surgery or laparotomy for gastric cancer respectively.Results:Compared with pre-operation,no change in the values of APTT and INR at the end of operation and 24th hour post-operation could be observed in both groups.The values of FIB and D-D markedly increased at the end of operation and 24th hour post-operation in laparoscopy groups,and there were significant difference(P0.05).The change of D-D in open group was similar to open group,while FIB increased when operations finished(P0.05)and 24h after operation(P0.05).The values of PT decreased sharply at 24th hour post-operation in the two groups,but there was no significant difference between 2 groups.Conclusions:The effect of laparoscopic surgery appears to make coagulation function vary more significantly than laparotomy,which would increase the incidence of deep vein thrombosis.So it is requisite to perform the treatment of anti-coagulation on the patients with laparoscopic surgery.