Comparative study of Laparoscopic surgery and laparotomy for rectal cancer on blood coagulation and fibrinolvsis

Objective To investigate the difference of laparoscopic surgery and laparotomy for rectal cancer on blood coagulation and fibrinolysis.Methods 96 patients were divided into laparoscopic gastric surgery group(laparoscopic group,50 cases) and abdominal surgery group(laparotomy group,46 cases).Blood coagulation and fibrinolysis was determined by detecting the value of Clauss solidification monitoring prothrombin time test(PT),activated partial thromboplastin time(APTT) and fibrinogen(FIB).Platelet was counted with blood analyzers(PLT),the prothrombin was calculated with International standardization of values(INR) and plasma D-dimer(D-D) was quantitatively determined using enzyme-linked immunosorbent assay method(ELISA) at pre-operation,1h and 24h hour after opration.Results 1h or 24h after operation,APTT INR and PLT did not have statistically significant changes,compared with the preoperative levels.In laparoscopic group,FIB and DD significantly increased(P0.05).FIB in laparotomy group did not significantly increase after 1h,but D-D after 1 and 24h significantly increased.D-D in the two groups both significantly increased after 24h,but there was a significant difference between them.Conclusion Laparoscopic surgery and laparotomy may result in hypercoagulable state in patients with rectal cancer,thus increase the risk of thrombosis after surgery,colorectal laparoscopic surgery has a greater impact on blood coagulation compared with laparotomy.