The application of remifentanil and propofol anesthesia for hysteroscopy

Objective To investigate the clinical effects and safety of remifentanil and propofol during operation of hysteroscopy.Methods 100 ASA Ⅰ～Ⅱ patients undergoing outpatient hysteroscopy were randomly allocated into two groups.In the remifentanil group(R group) anesthesia was induced with remifentanil 0.75μg/kg and propofol 2mg/kg,whereas in the fentanyl group(F group) was fentanyl 1.0μg/kg and propofol 2mg/kg,and was maintained with propofol when needed.The following were recorded and compared in the two groups:①the time of unconsciousness,recovery time from anesthesia,the side effects during recovery and the total doses of propofol;②hemodynamic and respiratory changes during anesthesia;③pain visual analog scale(VAS) and observers' assessment of alertness/sedation(OAA /S).Results The time of unconsciousness and recovery time from anesthesia at group R was significantly shorter compared with group F;The total doses of propofol used were less at group R than F group(P0.05).The MAP at group F was depressed significantly;The incidence of apnea at group R and F were 4 %and 24 %(P0.05).There was significant difference in the OAA/S between the groups(P0.05).However,There was no significant difference between groups regarding VAS of pain and the side effects during recovery(P0.05).Conclusion Remifentanil and propofol anesthesia appears to be superior for day-case hysteroscopy than fentanyl and propofol,with regards to the time of unconsciousness and recovery time from anesthesia and stably hemodynamics.