Propofol and remifentanii for deep sedation in children undergoing gastroscopy

Objective The aim of this study was to evaluate the safety and efficacy of a combination of propofol and remifentanil deep sedation in spontaneously breathing children aged 2 to 10-year-old undergoing gastroscopy.Methods 80 children undergoing gastroscopy were randomly allocated into two groups.In the remifentanil group(R group)anesthesia was induced with remifentanil 1μg/kg and propofol 2.5mg/kg,whereas in the fentanyl group(F group)was fentanyl 1μg/kg and propofol 2.5mg/kg,and was maintained with propofol when needed.The following were recorded and compared in the two groups:①the time of unconsciousness,recovery time from anesthesia,the side effects during anesthesia and recovery and total doses of propofol;②hemodynamic and respiratory changes during anesthesia.Results The time of unconsciousness,recovery time from anesthesia at group R was significantly shorter compared with group F;The total doses of propofol used were less at group R than F group(P0.05).The MAP at group F was depressed significantly.The incidence of apnea at group R and F were 8% and 22%(P0.05).Conclusion The combination of remifentanil and propofol in children aged 2 to 10-year-old undergoing gastroscopy can be considered safe,effective and acceptable.