2009•Journal of Medical ForumRequires access

Protective Effectiveness of 654-2 on Hepatic Ischemia-Reperfusion in Rats

Qu Qingshan

Abstract

Objective To study the protective effectiveness of 654-2 on hepatic ischemia-reperfusion injury in rats.Methods Fourty male Wistar rats were randomly assigned into the control group(n=20) and preconditioning group(n=20)(654-2 group).The animals were injected 654-2 in portal vein.After 45 minutes-closure of the animals'left portal veins,blood sample、 hepatic tissue regular-dye and bcl-2 dye were studied 3 hours after the re-open.Results In 654-2 group ALT were significantly decreased.Microscopic bcl-2 dye and their GSH of serum were singnificantly increased.Conclusion It is suggested that 654-2 has protective effect on hepatic ischemia-reperfusion injury.

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Key concepts: Medicine, Ischemia, Portal vein, Reperfusion injury, Vein, Tail vein, Internal medicine, Anesthesia