2009•Central Plains Medical JournalRequires access

Influence and protective effectiveness of GSH on hepatic ischemia-reperfusion in rats

Guoyong Chen, Sun Jian-jun, Miao Shuzhai, Qu Qingshan, Xing Li, Cai Wen-li

Abstract

Objective To study the protective effectiveness of GSH on hepatic ischemia - reper-fusion injury in rats. Methods Twenty male Wistar rats were randomly assigned into the control group (n = 10) and preconditioning group(n = 10)(GSH group). The animals were injected GSH in portal vein. After 45 minutes - closure of the animals' left portal veins, blood sample, hepatic tissue regular -dye and P - selectin dye were studied 3 hours after the re - open. Results In GSH group SOD were sig-nificantly increased, Microscopic P - selectin dye and their ALT of serum were significantly decreased.Conclusions It is suggested that GSH has protective effect on hepatic ischemia -reperfusion injury. Key words: Liver; Reperfusion injury ; Rats ; GSH ; P - selectin protein ; SOD

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Key concepts: Glutathione, Ischemia, Medicine, Reperfusion injury, Portal vein, Internal medicine, Endocrinology, Chemistry