2005•Journal of Medical ForumRequires access

The Protective Effects of 654-2 on Hepatic Ischemia-Reperfusion in Rats

Zhigang Pang

Abstract

Objective To study the protective effects of 654-2 on hepatic ischemia-reperfusion injury (I-R) and P-selectin protein expression in rats. Methods 20 male Wistar rats were randomly assigned into the control group(I-R group) and preconditioning group(654-2 group).After 45 minutes closure of the animals'left portal veins, blood sample、ALT、GSH、 hepatic tissue regular-dye and P-selectin dye were studied 3 hours after the re-open. Results Compared with I-R group,654-2 group ALT、GSH were significantly decreased(P0.01).Microscopic P-selectin dye were singnificantly decreased due to effect of 654-2.Conclusion 654-2 has protective effectiveness on hepatic ischemia-reperfusion injury by dreasing the expression of hepatic P-selectin.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Ischemia, Medicine, Reperfusion injury, Internal medicine, P-selectin, Glutathione, Endocrinology, Chemistry