Influencing factors of pregnancy rate of intrauterine insemination with male infertility

Objective To study the relative factors affecting the clinical pregnancy rate of intrauterine insemination(IUI)with infertility caused by men.Methods The clinical data of 337infertile couples who undergoing 667IU cycles were analyzed.Relationship between clinical pregnancy rate and couples' age,duration of infertility, maternal body mass index(BMI),ovulation induction and processed total motile sperm count(PTMS)were investigated.Results The clinical pregnancy rate was significantly lower in the patients with female and male age≥35 years(12.6%and 15.9%respectively);Compared with natural cycles,the clinical pregnancy rate was statistically higher(25.5%)in clomiphene(CC)combined with gonadotrophin cycles;When PTMS 5×106,the clinical pregnancy rate was dramatically decreased(8.3%,P0.05).Conclusions The age of female and male should be considered during IUI therapy,optimal ovulation can help to increase the clinical pregnancy rate.The clinical pregnancy rate will statistically decrease when PTMS5×106,the patients can choose IVF-ET or ICSI-ET to improve the outcome.