Study on the changes of von willebrand factor and D-dimer in diabetics

Objective To study the clinical significance of the changes of von willebrand factor(VWF) and D-dimer(D-D) in patients with 2-type diabetes mellitus(2-DM) and with 2-DM and essential hypertension(EH).Methods 83 cases were divided into three groups including 38 cases of 2-DM,20 cases of 2-DM and EH and 25 cases of healthy controls,plasma VWF and D-D were measured in all cases.Results Compared with the control group,the concentration of VWF and D-D were found to be signifcantly higher in 2-DM group(157.47±45.77%,0.51±0.10mg/L vs 126.26±20.42%,0.24±0.09mg/L,P0.01),however 2-DM and EH group more than 2-DM group(186.40±25.56%,0.80±0.28mg/L vs 157.47±45.77%,0.51±0.10mg/L,P0.05).Conclusion There is significantly relationship between the higher concentration of VWF and D-D and vascular disease in 2-DM patients.It is important clinical value to measure plasma VWF and D-D for the prevention and treatment of vascular disturbance in 2-DM patients.