ScholarLens Back to search
2007•Zhejiang Medical JournalRequires access

Inhibitory effect of oridonin on bladder cancer T24 cells and its mechanism

Guoqing Ding

Open publisher page 0 citations

Abstract

Objective To investigate the inhibitory effect of oridonin on bladder cancer T24 cells and its mechanism. Methods Different concentrations of oridonin were added in culture medium. The inhibitory rate of the T24 cells was measured by MTT assay, cell apoptosis was observed by flow cytometry (FCM ) and Hoechst 33258 fluorescence staining. Results Oridonin inhibited the growth of T24 cells and induced cell apoptosis significantly. The suppression was both in a time- and dose-dependent manner. Conclusion Oridonin has inhibitory effect on bladder cancer T24 cells in vitro, which might be associated with the cell apoptosis.

About this research paper

What this paper is about

Objective To investigate the inhibitory effect of oridonin on bladder cancer T24 cells and its mechanism. Methods Different concentrations of oridonin were added in culture medium. The inhibitory rate of the T24 cells was measured by MTT assay, cell apoptosis was observed by flow cytometry (FCM ) and Hoechst 33258 fluorescence staining. Results Oridonin inhibited the growth of T24 cells and induced cell apoptosis significantly. The suppression was both in a time- and dose-dependent manner. Conclusion Oridonin has inhibitory effect on bladder cancer T24 cells in vitro, which might be associated with the cell apoptosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the inhibitory effect of oridonin on bladder cancer T24 cells and its mechanism. Methods Different concentrations of oridonin were added in culture medium. The inhibitory rate of the T24 cells was measured by MTT assay, cell apoptosis was observed by flow cytometry (FCM ) and Hoechst 33258 fluorescence staining. Results Oridonin inhibited the growth of T24 cells and induced cell apoptosis significantly. The suppression was both in a time- and dose-dependent manner. Conclusion Oridonin has inhibitory effect on bladder cancer T24 cells in vitro, which might be associated with the cell apoptosis.

Key concepts: Apoptosis, Flow cytometry, Medicine, Inhibitory postsynaptic potential, MTT assay, Bladder cancer, Cell, In vitro

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Inhibitory effect of oridonin on bladder cancer T24 cells and its mechanism — Research Paper | ScholarLens