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2011•Unpublished venueRequires access

Clinical significance of VEGF expression in transitional cell carcinoma of bladder

Ying-hong Gao

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Abstract

Objective:To evaluate the expression level and clinical significance of vascular endothelial cell growth factor(VEGF) in transitional cell carcinoma of bladder(BTCC).Methods:The expression level of VEGF protein in 63 cases of BTCC,21 cases of papilloma of bladder and 13 cases of normal bladder mucosa were tested by the method of PV-6000 immunohistochemistry.Results: The positive expression rate of VEGF in BTCC tissues was higher than that in papilloma and normal tissues of bladder.The positive expression level was closely related to clinical stage of BTCC but was not significantly direct related to tumor cell nuclear grade.Conclusion: VEGF is closely associated with the carcinogenesis /development and prognosis of BTCC.

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What this paper is about

Objective:To evaluate the expression level and clinical significance of vascular endothelial cell growth factor(VEGF) in transitional cell carcinoma of bladder(BTCC).Methods:The expression level of VEGF protein in 63 cases of BTCC,21 cases of papilloma of bladder and 13 cases of normal bladder mucosa were tested by the method of PV-6000 immunohistochemistry.Results: The positive expression rate of VEGF in BTCC tissues was higher than that in papilloma and normal tissues of bladder.The positive expression level was closely related to clinical stage of BTCC but was not significantly direct related to tumor cell nuclear grade.Conclusion: VEGF is closely associated with the carcinogenesis /development and prognosis of BTCC.

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Available abstract

Objective:To evaluate the expression level and clinical significance of vascular endothelial cell growth factor(VEGF) in transitional cell carcinoma of bladder(BTCC).Methods:The expression level of VEGF protein in 63 cases of BTCC,21 cases of papilloma of bladder and 13 cases of normal bladder mucosa were tested by the method of PV-6000 immunohistochemistry.Results: The positive expression rate of VEGF in BTCC tissues was higher than that in papilloma and normal tissues of bladder.The positive expression level was closely related to clinical stage of BTCC but was not significantly direct related to tumor cell nuclear grade.Conclusion: VEGF is closely associated with the carcinogenesis /development and prognosis of BTCC.

Key concepts: Clinical significance, Immunohistochemistry, Bladder Neoplasm, Medicine, Stage (stratigraphy), Transitional cell carcinoma, Pathology, Carcinogenesis

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